SA09-Cu [155641-16-0]

MedChem Express

SA09-Cu [155641-16-0]

10

155641-16-0

Research Use Only

C8H16CuN2O2S4

364.03

SA09-Cu is a noncompetitive and potent NDM-1 inhibitor with an IC50 of 9.6 nM. SA09-Cu can convert NDM-1 into an inactive state by oxidizing the Zn(II)-thiolate site of the enzyme and avoids to be reduced by intracellular thiols of bacteria. SA09-Cu exhibits excellent inhibition against a series of clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) in restoring the Meropenem (HY-13678) effect, and slows down the development of carbapenem resistance[1].

OCCN(C)C1=[S-][Cu+2]2(SC(N(C)CCO)=[S-]2)S1

12131703