Sacibertinib [1351941-69-9]

MedChem Express

Sacibertinib [1351941-69-9]

10

1351941-69-9

Research Use Only

C32H31ClN6O4

599.08

Sacibertinib is a tyrosine kinase (Trk) inhibitor with EC50 value of 110 nM and 244 nM for EGFR-TK phosphorylation and HER2, respectively. Antineoplastic activity[1].

CN(C)C/C=C/C(NC1=CC(C(NC2=CC(Cl)=C(C=C2)OCC3=CC=CC=N3)=C(C#N)C=N4)=C4C=C1O[C@H]5CCOC5)=O

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