Samuraciclib hydrochloride hydrate

MedChem Express

Samuraciclib hydrochloride hydrate

10

Research Use Only

98.6%

C22H30N6O.(2.5HCl).(3.7H2O)

552.33

Samuraciclib (CT7001) hydrochloride hydrate is a potent, selective, ATP-competitive and orally active CDK7 inhibitor, with an IC50 of 41 nM. Samuraciclib hydrochloride hydrate displays 45-, 15-, 230- and 30-fold selectivity over CDK1, CDK2 (IC50 of 578 nM), CDK5 and CDK9, respectively. Samuraciclib hydrochloride hydrate inhibits the growth of breast cancer cell lines with GI50 values between 0.2-0.3 microM. Samuraciclib hydrochloride hydrate has anti-tumor effects.

O[C@H]1CNCC[C@@H]1CNC2=NC3=C(C(C)C)C=NN3C(NCC4=CC=CC=C4)=C2.Cl.O.[2.5].[3.7]

2°C to 8°C,-20°C,-80°C

12352200