SARS-CoV-2-IN-109

MedChem Express

SARS-CoV-2-IN-109

5

SARS-CoV-2-IN-109 (compound 50) is an inhibitor targeting SARS-CoV with in vivo anti-infection activity. SARS-CoV-2-IN-109 targets the interaction between the SARS-CoV-2 Spike receptor-binding domain (RBD) and the human receptor angiotensin-converting enzyme 2 (ACE2) (EC 50 =26.5 microM), blocking the entry of SARS-CoV-2 into VeroE6 cells (EC 50 =17.0 microM). The CC50 of SARS-CoV-2-IN-109 for VeroE6 cells is >100 microM [1] .

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