SARS-CoV-2-IN-81

MedChem Express

SARS-CoV-2-IN-81

14

Research Use Only

C25H20N4O2

408.45

SARS-CoV-2-IN-81 (compound 12e) is a potent AAK1 inhibitor with an IC 50 value of 9.38 nM. SARS-CoV-2-IN-81 shows anti-viral property against SARS-CoV-2 . SARS-CoV-2-IN-81 attenuates AAK1-induced phosphorylation of AP2M1 threonine 156 and disrupts the direct interaction between AP2M1 and ACE2, ultimately inhibiting SARS-CoV-2 infection [1] .

C12=CC(C3=CN=C(NC=C4C#CC5=CN=CC=C5)C4=C3)=CC=C1N(CCOC6)C6CO2

12352200