SARS-CoV-2 Mpro-IN-41

MedChem Express

SARS-CoV-2 Mpro-IN-41

5

Research Use Only

C27H23ClN4O3S

519.01

SARS-CoV-2 Mpro-IN-41 (Compound 7e) is an orally active inhibitor of COX-2 and SARS-CoV-2 M pro (IC50 values are 9.66 microM and 13.24 microM, respectively). SARS-CoV-2 Mpro-IN-41 also has a certain inhibitory activity against COX-1 (IC50: 46.11 microM). SARS-CoV-2 Mpro-IN-41 can significantly inhibit the expression of inflammatory-related cytokines (such as TNF-alpha, IL-6, IL-1beta) and exert anti-inflammatory effects. SARS-CoV-2 Mpro-IN-41 exerts anti-inflammatory and antiviral effects by selectively inhibiting COX-2 and SARS-CoV-2 M pro. SARS-CoV-2 Mpro-IN-41 can be used for anti-inflammatory and anti-coronavirus research[1].

O=C(C(C1=NN(C2=CC=C(S(=O)(C)=O)C=C2)C(C3=CC=C(Cl)C=C3)=C1)=C(C)N4C)N4C5=CC=CC=C5

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