SARS-CoV-2 PLpro-IN-3

MedChem Express

SARS-CoV-2 PLpro-IN-3

102

Research Use Only

C31H29N5O4

535.59

SARS-CoV-2 PLpro-IN-3 (Compound 15) is a covalent inhibitor of the SARS-CoV-2 papain-like protease (PLpro), with an IC50 of 25 nM. SARS-CoV-2 PLpro-IN-3 has similar inhibitory activity against SARS-CoV PLpro (IC50 = 59 nM), but shows no inhibitory effect on human ubiquitin-specific protease 7 (USP7). The EC50 of SARS-CoV-2 PLpro-IN-3 in inhibiting SARS-CoV-2 replication in cells is 96 nM, significantly reducing the viral titer and viral RNA levels. SARS-CoV-2 PLpro-IN-3 can be used for studying SARS-CoV-2 drug resistance mutations[1].

O=C(N[C@@H](C1=C2C=CC=CC2=CC=C1)C)C3=CC=CC=C3CCC(NNC(/C=C/C(NC4=CC=CN=C4)=O)=O)=O

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