SARS-CoV-IN-5
HY-163913
Molecular Weight629.48
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameSARS-CoV-IN-5
- Delivery Days Customer9
- CertificationResearch Use Only
- Molecular FormulaC28H30BrFN6O5
- Molecular Weight629.48
- Scientific DescriptionSARS-CoV-IN-5 (compound 49) is a highly selective, nonpeptidic and noncovalent 3CL pro inhibitor with IC 50 s of 38 nM, 21.1 nM and 86 nM for 3CL pro of SARS-CoV-1, SARS-CoV-2, Bat coronavirus WIV1, respectively. SARS-CoV-IN-5 inhibits the replication of the SARS-CoV-2 delta variant with an EC 50 of 0.272 microM. SARS-CoV-IN-5 significantly reduces the lung viral copies in a K18-hACE2 transgenic mouse model. SARS-CoV-IN-5 has good target-specific and potential broad-spectrum anticoronavirus activities against SARS-CoV-1, WIV1, MERS, HCoV-OC43, HCoV-229E, and HKU9 [1] .
- SMILESO=C(N1CCN(C)CC1)C2=CC(Br)=CC([N+]([O-])=O)=C2N[C@H]3[C@H](CCCC3)NC(C(C4=CC=CC(F)=C4N5)=CC5=O)=O
- UNSPSC12352200