Bio-Connect

SARS-CoV-IN-5

HY-163913
MedChem Express
Molecular Weight629.48
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    SARS-CoV-IN-5
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Molecular Formula
    C28H30BrFN6O5
  • Molecular Weight
    629.48
  • Scientific Description
    SARS-CoV-IN-5 (compound 49) is a highly selective, nonpeptidic and noncovalent 3CL pro inhibitor with IC 50 s of 38 nM, 21.1 nM and 86 nM for 3CL pro of SARS-CoV-1, SARS-CoV-2, Bat coronavirus WIV1, respectively. SARS-CoV-IN-5 inhibits the replication of the SARS-CoV-2 delta variant with an EC 50 of 0.272 microM. SARS-CoV-IN-5 significantly reduces the lung viral copies in a K18-hACE2 transgenic mouse model. SARS-CoV-IN-5 has good target-specific and potential broad-spectrum anticoronavirus activities against SARS-CoV-1, WIV1, MERS, HCoV-OC43, HCoV-229E, and HKU9 [1] .
  • SMILES
    O=C(N1CCN(C)CC1)C2=CC(Br)=CC([N+]([O-])=O)=C2N[C@H]3[C@H](CCCC3)NC(C(C4=CC=CC(F)=C4N5)=CC5=O)=O
  • UNSPSC
    12352200