Bio-Connect

SARS-CoV-IN-5

ORB2664654
Biorbyt
Estimated Purity98.00%
Product group Chemicals
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Overview

  • Supplier
    Biorbyt
  • Product Name
    SARS-CoV-IN-5
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    98.00%
  • Scientific Description
    SARS-CoV-IN-5 (compound 49) is a high-selectivity, non-peptide, non-covalent 3CLpro inhibitor. It exhibits IC50 values of 38 nM, 21.1 nM, and 86 nM against the 3CLpro of SARS-CoV-1, SARS-CoV-2, and bat coronavirus WIV1, respectively. SARS-CoV-IN-5 inhibits the replication of the SARS-CoV-2 Delta variant with an EC50 of 0.272 microM. The compound notably reduces viral copy numbers in the lungs of K18-hACE2 transgenic mouse model. Furthermore, SARS-CoV-IN-5 demonstrates broad-spectrum antiviral activity against SARS-CoV-1, WIV1, MERS, HCoV-OC43, HCoV-229E, and HKU9, targeting these coronaviruses effectively.
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200