SARS-CoV-IN-5
ORB2664654
Estimated Purity98.00%
Product group Chemicals
Overview
- SupplierBiorbyt
- Product NameSARS-CoV-IN-5
- Delivery Days Customer10
- CertificationResearch Use Only
- Estimated Purity98.00%
- Scientific DescriptionSARS-CoV-IN-5 (compound 49) is a high-selectivity, non-peptide, non-covalent 3CLpro inhibitor. It exhibits IC50 values of 38 nM, 21.1 nM, and 86 nM against the 3CLpro of SARS-CoV-1, SARS-CoV-2, and bat coronavirus WIV1, respectively. SARS-CoV-IN-5 inhibits the replication of the SARS-CoV-2 Delta variant with an EC50 of 0.272 microM. The compound notably reduces viral copy numbers in the lungs of K18-hACE2 transgenic mouse model. Furthermore, SARS-CoV-IN-5 demonstrates broad-spectrum antiviral activity against SARS-CoV-1, WIV1, MERS, HCoV-OC43, HCoV-229E, and HKU9, targeting these coronaviruses effectively.
- Storage Instruction-20°C
- UNSPSC12352200