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ProductsBack/Sauchinone [177931-17-8]
Chemical Structure
Chemical Structure
Chemical Structure

Sauchinone [177931-17-8]

Research Use Only
AG-CN2-0032
AdipoGen Life Sciences
CAS Number177931-17-8
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight356.4
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Sauchinone [177931-17-8]
  • Delivery Days Customer
    10
  • CAS Number
    177931-17-8
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C20H20O6
  • Molecular Weight
    356.4
  • Scientific Description
    Chemical. CAS: 177931-17-8. Formula: C20H20O6. MW: 356.4. Isolated from Saururus chinensis. Hepatoprotective antioxidant. Anti-inflammatory. Suppresses NF-kB p65 activity. Neuroprotective. Apoptosis inhibitor. Bone resorption/osteoclastogenesis inhibitor. Reduces ROS formation. Antiseptic. AMP-activated kinase (AMPK) activator. Akt phosphorylation inhibitor. - Hepatoprotective antioxidant [1, 2, 9]. Anti-inflammatory. Suppresses NF-kB p65 activity [3, 5]. Neuroprotective. Apoptosis inhibitor [4]. Bone resorption/osteoclastogenesis inhibitor. Reduces ROS formation [6]. Antiseptic [7]. AMP-activated kinase (AMPK) activator [8]. Akt phosphorylation inhibitor [10]. Arginase II inhibitor [11].
  • SMILES
    [H][C@]12C[C@@H](C)[C@H](C)[C@@]3([H])C4=C(O[C@]5(OCOC5=CC1=O)[C@@]23[H])C=C1OCOC1=C4
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Sauchinone, a lignan from Saururus chinensis, attenuates CCl4-induced toxicity in primary cultures of rat hepatocytes: S.H. Sung, et al.; Biol. Pharm. Bull. 23, 666 (2000)
  • Hepatoprotective diastereomeric lignans from Saururus chinensis herbs: S.H. Sung & Y.C. Kim; J. Nat. Prod. 63, 1019 (2000)
  • Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation: A.K. Lee, et al.; Br. J. Pharmacol. 139, 11 (2003)
  • Sauchinone, a lignan from Saururus chinensis, inhibits staurosporine-induced apoptosis in C6 rat glioma cells: H. Song, et al.; Biol. Pharm. Bull. 26, 1428 (2003)
  • Sauchinone, a lignan from Saururus chinensis, suppresses iNOS expression through the inhibition of transactivation activity of RelA of NF-kappaB: B.Y. Hwang, et al.; Planta Med. 69, 1096 (2003)
  • Inhibition of osteoclast differentiation and bone resorption by sauchinone: K.Y. Han, et al.; Biochem. Pharmacol. 74, 911 (2007)
  • Protective effect of lignans against sepsis from the roots of Saururus chinensis: C.S. Seo, et al.; Biol. Pharm. Bull. 31, 523 (2008)
  • Efficacy of sauchinone as a novel AMPK-activating lignan for preventing iron-induced oxidative stress and liver injury: Y.W. Kim, et al.; Free Radic. Biol. Med. 47, 1082 (2009)
  • Nrf2-mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKCdelta-GSK3beta pathway: H.Y. Kay, et al.; Br. J. Pharmacol. 163, 1653 (2011)
  • Sauchinone suppresses lipopolysaccharide-induced inflammatory responses through Akt signaling in BV2 cells: E.Y. Yang, et al.; Int. Immunopharmacol. 14, 188 (2012)