SB 203580 hydrochloride

TargetMol Chemicals

SB 203580 hydrochloride

14

869185-85-3

Chemical

SB 203580 hydrochloride

C21H17ClFN3OS

413.9

Adezmapimod (SB 203580) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC 50 s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38bèta2, respectively. Adezmapimod hydrochloride inhibits LCK, GSK3bèta and PKBalfa with IC 50 s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod hydrochloride is also an activator of autophagy and mitophagy [1].

3 years

Cl.CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1

-20°

12352200