SB-218078

MedChem Express

SB-218078 [135897-06-2]

10

135897-06-2

Research Use Only

98.30

C24H15N3O3

393.39

SB-218078 is a potent, selective, ATP-competitive and cell-permeable checkpoint kinase 1 (Chk1) inhibitor that inhibits Chk1 phosphorylation of cdc25C with an IC 50 of 15 nM. SB-218078 is less potently inhibits Cdc2 ( IC 50 of 250 nM) and PKC ( IC 50 of 1000 nM). SB-218078 causes apoptosis by DNA damage and cell cycle arrest [1] [2] [3] .

O=C1NC(C(C2=C3N(C4CCC5O4)C6=CC=CC=C62)=C1C7=C3N5C8=CC=CC=C78)=O

-20°C,2°C to 8°C

12352200