SB-334867 [249889-64-3]

MedChem Express

SB-334867 [249889-64-3]

5

249889-64-3

Research Use Only

98.78%

C17H14ClN5O2

355.78

SB-334867 (SB 334867A) is an excellent,selective and blood-brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pKb=7.4), 100-fold over 5-HT2B, 5-HT2C with pKi values of 5.4 and 5.3, respectively. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo.

O=C(NC1=CC(OC(C)=N2)=C2C=C1)NC3=CC=NC4=CC=CN=C43.Cl

2°C to 8°C,-20°C,-80°C

12352200