SB-334867 (free base)

MedChem Express

SB-334867 (free base) [792173-99-0]

10

792173-99-0

Research Use Only

99.88

C17H13N5O2

319.32

SB-334867 free base (SB334867A free base) is an excellent, selective and blood-brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 ( pK b =7.4), 100-fold over 5-HT 2B , 5-HT 2C with pK i values of 5.4 and 5.3, respectively [1] . SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo [2] [3] .

O=C(NC1=CC(OC(C)=N2)=C2C=C1)NC3=CC=NC4=CC=CN=C43

-20°C,2°C to 8°C

12352200