SB-431542 [301836-41-9]

MedChem Express

SB-431542 [301836-41-9]

10

301836-41-9

Research Use Only

99.85

C22H16N4O3

384.39

SB-431542 is a TGF-beta receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC50 values of 1 microM, 0.75 microM and 2 microM, respectively. SB-431542 also inhibits TGF-beta-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways[1][2][3].

O=C(C1=CC=C(C=C1)C2=NC(C3=CC=C4OCOC4=C3)=C(N2)C5=NC=CC=C5)N

-20°C,2°C to 8°C

12352200