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SB-505124 hydrochloride [356559-13-2]
T21637
Overview
- SupplierTargetMol Chemicals
- Product NameSB-505124 hydrochloride [356559-13-2]
- Delivery Days Customer14
- CAS Number356559-13-2
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameSB-505124 hydrochloride
- Molecular FormulaC20H22ClN3O2
- Molecular Weight371.86
- Scientific DescriptionSB-505124 hydrochloride (SB505124 hydrochloride) is an orally available, selective and potent inhibitor of TGF-beta type I receptors (ALK4, ALK5, ALK7) with IC50 values of 129 nM and 47 nM for ALK4 and ALK5, respectively. SB-505124 hydrochloride inhibits IL-6 production by synovial explants and reduces Th17 differentiation in mice by decreasing Il17a and Rorc gene expression and IL-17 protein production.SB-505124 hydrochloride is used in the study of colorectal cancer.
- Shelf life instruction3 years
- SMILESCl.N=1C(=CC=CC1C)C=2N=C(NC2C=3C=CC=4OCOC4C3)C(C)(C)C
- Storage Instruction-20°C
- UNSPSC12352200