SB-612111 (hydrochloride)

MedChem Express

SB-612111 (hydrochloride)

10

Research Use Only

99.26

C24H30Cl3NO

454.86

SB-612111 hydrochloride hydrochloride is a novel and potent opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 ( K i =0.33 nM). SB-612111 hydrochloride exhibits selectivity for micro-,?kappa- and?delta-receptors with K i values of?57.6 nM, 160.5 nM and 2109 nM, respecticely. SB-612111 hydrochloride effectively antagonizes the pronociceptive action of Nociceptin (HY-P0183) in an acute pain model [1] .

O[C@H]1C[C@@H](CN2CCC(C3=C(Cl)C=CC=C3Cl)CC2)CCC4=C(C)C=CC=C41.[H]Cl

-20°C,2°C to 8°C

12352200