SB02024
ORB1146672
Molecular Weight345.36
Product group Chemicals
Overview
- SupplierBiorbyt
- Product NameSB02024
- Delivery Days Customer10
- CertificationResearch Use Only
- Molecular FormulaC16H22F3N3O2
- Molecular Weight345.36
- Scientific DescriptionSB02024 is a novel highly potent, selective, ATP competitive, orally active inhibitor of vacuolar protein sorting 34 (Vps34) with Kd of 1 nM, > 1000 times selective towards other PI3K isoenzymes; SB02024 is also highly selective at 1 uM in the DiscoveRx ScanMax panel of 468 kinases; reduces the number of GFP-2xFYVE puncta with IC50 of 14 nM, induces a dose-dependent increase in levels of NCOA4 and p62; blocks autophagy in vitro and reduces xenograft growth of two breast cancer cell lines, MDA-MB-231 and MCF-7; also significantly potentiates cytotoxicity of Sunitinib and Erlotinib in MCF-7 and MDA-MB-231 in vitro.
- SMILESO=C1NC(N2[C@@H](C(F)(F)F)CCCC2)=CC(N3[C@H](C)COCC3)=C1
- UNSPSC12352200