SBI-0640726

Biorbyt

SBI-0640726

10

Research Use Only

98.00%

C23H15ClN2O2

386.83

SBI-0640726, an eIF4G1 inhibitor, exhibits antiproliferative activity against melanoma. It disrupts the eIF4F translation initiation complex by inhibiting the AKT and NF-kB signaling pathways. Additionally, SBI-0640726 inhibits the growth of melanoma with NRAS and BRAF mutations in vitro.

C(/C=C/C1=CC=CC=N1)(=O)C2=C(C=3C(NC2=O)=CC=C(Cl)C3)C4=CC=CC=C4

-20°C

12352200