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sbp-7455 [1884222-74-5]

sbp-7455 [1884222-74-5]

T8850
TargetMol Chemicals
CAS Number1884222-74-5
Product group Chemicals
Estimated Purity99.03%
Molecular Weight354.33
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    sbp-7455 [1884222-74-5]
  • Delivery Days Customer
    4
  • CAS Number
    1884222-74-5
  • Certification
    Research Use Only
  • Chemical Name
    sbp-7455
  • Estimated Purity
    99.03%
  • Molecular Formula
    C16H17F3N4O2
  • Molecular Weight
    354.33
  • Scientific Description
    SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.
  • Shelf life instruction
    3 years
  • SMILES
    COc1ccc(Nc2ncc(c(NC3CC3)n2)C(F)(F)F)cc1OC
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Ren H, Bakas NA, Vamos M, et al. Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2020,63(23):14609-14625. doi: 10.1021/acs.jmedchem.0c00873
    Read this paper

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