SCH-23390 (maleate)

MedChem Express

SCH-23390 (maleate) [87134-87-0]

10

87134-87-0

Research Use Only

C21H22ClNO5

403.86

SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective dopamine D 1 -like receptor antagonist with K i s of 0.2 nM and 0.3 nM for the D 1 and D 5 receptor , respectively. SCH-23390 maleate is a potent and high efficacy human 5-HT 2C receptor agonist with a K i of 9.3 nM. SCH-23390 maleate also binds with high affinity to the 5-HT 2 and 5-HT 1C receptors . SCH-23390 maleate inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC 50 of 268 nM [1] [2] [3] .

OC1=C(Cl)C=C2CCN(C)C[C@H](C3=CC=CC=C3)C2=C1.O=C(O)/C=C\C(O)=O

12352200