SCH442416

MedChem Express

SCH442416 [316173-57-6]

10

316173-57-6

Research Use Only

99.68

C20H19N7O2

389.41

SCH442416 is a potent, selective and brain-penetrant antagonist of adenosine A 2A receptor (A 2A R) , with K i s of 0.048 and 0.5 nM for human and rat A 2A R respectively. SCH442416 displays more than 23000-fold selectivity over A 1 R, A 2B R, and A 3 R (K i =1111, 10000, and 10000 nM, respectively). SCH442416 can be used for imaging of adenosine A 2A receptors in rat and primate brain [1] [2] .

NC1=NC(N(CCCC2=CC=C(OC)C=C2)N=C3)=C3C4=NC(C5=CC=CO5)=NN14

-20°C,2°C to 8°C

12352200