SCH529074

MedChem Express

SCH529074 [922150-11-6]

10

922150-11-6

Research Use Only

99.73

C31H36Cl2N6

563.56

SCH529074 is a potent and orally active p53 activator. SCH529074 binds specifically and conformation-dependently to p53 DBD ( DNA binding domain) with a K i of 1-2 microM in a saturable manner. SCH529074 restores mutant p53 function and interrupts HDM2-mediated ubiquitination of wild Type p53. SCH529074 can be used for the study of non-small-cell lung carcinoma (NSCLC) [1] [2] .

CN(C)CCCNC1=C2C=CC=CC2=NC(CN3CCN(C(C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5)CC3)=N1

-20°C,2°C to 8°C

12352200