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SCH529074

HY-110088
MedChem Express
CAS Number922150-11-6
DownloadMSDS
Product group Chemicals
Estimated Purity99.73
Molecular Weight563.56
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Overview

  • Supplier
    MedChem Express
  • Product Name
    SCH529074 [922150-11-6]
  • Delivery Days Customer
    10
  • CAS Number
    922150-11-6
  • Certification
    Research Use Only
  • Estimated Purity
    99.73
  • Molecular Formula
    C31H36Cl2N6
  • Molecular Weight
    563.56
  • Scientific Description
    SCH529074 is a potent and orally active p53 activator. SCH529074 binds specifically and conformation-dependently to p53 DBD ( DNA binding domain) with a K i of 1-2 microM in a saturable manner. SCH529074 restores mutant p53 function and interrupts HDM2-mediated ubiquitination of wild Type p53. SCH529074 can be used for the study of non-small-cell lung carcinoma (NSCLC) [1] [2] .
  • SMILES
    CN(C)CCCNC1=C2C=CC=CC2=NC(CN3CCN(C(C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5)CC3)=N1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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