(Cell) Culture

Antibodies

Arrays / Slides

Assays

Blocking peptide

cDNA

Chemicals

Chemokines / cytokines

CRISPR / Cas9

DNA / RNA / Vectors

Fluorescent conjugated

Genome Editing and Engineering

Ligases / phosphatases / kinases

Lysates

Lysates / Extracts

Molecular Biology

Oligo

Overexpressing lysates

Peptides

Plasmid / vector

Primary

Primer

Primer / probes / oligo

Proteins

Proteins / Signaling Molecules

Real time PCR

Recombinant protein

Restriction / modifying enzymes

shRNA

siRNA

Standards / controls

Tissue

Bovine

Canine

Equine

Human

Mammals

Monkey

Mouse

Porcine

Primate

Rabbit

Sheep

Reactivity

ELISA

Flow Cytometry

ImmunoCytoChemistry

ImmunoFluorescence

ImmunoHistoChemistry

ImmunoHistoChemistry Frozen

ImmunoHistoChemistry Paraffin

ImmunoPrecipitation

Western Blot

Applications

CDC7

Dbf4

DBF4

DBF4B

Nup358

ZDBF2

Target

Goat

Host

Abnova

Antibodies.com

Assay Genie

Atlas Antibodies

Aviva Systems Biology

Biomatik

Biorbyt

Bioss Antibodies

Biosynth

BPS Bioscience

Cusabio

ELK Biotechnology

Everest Biotech

GeneTex

HUABIO

LifeSpan BioSciences

MedChem Express

MyBioSource

OriGene

Santa Cruz Biotechnology

SignalChem

Sino Biological

TargetMol Chemicals

Wuhan Fine Biotech

Supplier

Monoclonal

Polyclonal

Clonality

AlexaFluor 350

AlexaFluor 488

AlexaFluor 555

AlexaFluor 594

AlexaFluor 647

AlexaFluor 680

AlexaFluor 750

Alk. Phosphatase

Biotin

Cy5.5

Double Conjugated

FITC

Tricolor

Unconjugated

Conjugate

IgG1

Isotype

Research Use Only

Certification

10926

27214

312046

43041

57683

80174

8317

Gene ID

O00311

Q8NFT6

Q9HCK1

Q9QZ41

Q9UBU7

Q9VBU7

Protein ID

Bio-Connect Diagnostics

Bio-Connect Life Sciences

Business unit

CDC7 antibody [DCS-341] is validated for ELISA, ICC, IF, IP, WB & tested in Human. GeneTex is available at Bio-Connect

CDC7 antibody [DCS-341] antibody | GTX10535 | GeneTex

CDC7 antibody [DCS-341]

DNA replication in eukaryotic cells is dependent on the phosphorylation of the pre-replicative complex (preRC) at the origin of replication. Two complexes of proteins mediate this event, the cyclin dependent kinase (CDK) complex, and the Cdc7 kinase-ASK complex. The involvement of the latter complex in DNA replication was shown by different assays such as injection of antibodies against Cdc7 kinase that caused inhibition of DNA replication. Furthermore, mutant mice lacking mouse Cdc7 kinase are early embryonic lethal at E3.5-6.5.1-3 Human Cdc7 kinase consists of 574 amino acids with a molecular weight of 55 kDa. The protein shares about 45% identity with yeast Cdc7 kinase in the kinase domain. Cdc7 kinase is inert as a kinase unless it is activated by the ASK protein (the human homologue of yeast Dbf4). The expression of ASK is tightly regulated with cell cycle. ASK protein level is very low at the M-G1 phase and increases at late G1, staying high during S phase and through G2 phase. As a consequence, the activity of Cdc7 kinase oscillates during cell cycle. The major targets of Cdc7 kinase are proteins that belong to the MCM complex (mini chromosome maintenance proteins). The phosphorylation of proteins of the MCM complex by Cdc7 kinase is important for complex reorganization and duplex unwinding activity in the replication fork. Cdc7 kinase was also found to be important in meiosis, checkpoint responses, maintenance of chromosome structure, and repair.

Website

Tech support

Our company

Our team

Divisions

Vacatures

Events

Promotions

About us

Contact

Our people

Products

Our Company

Suppliers

News

Bio-Connect

Biotech, Pharma & CRO

Academia

Diagnostics

Environment

Food

Veterinary

Industries

Disclaimer

Privacy Statement

Terms and conditions

Are you looking for specific products, alternatives, documentation or need assistance with solving product related issues? Let our in-house technical support team help you.

We support your research

<p>For 15 years, we connect life science researchers specialized in the import and distribution of life science reagents from global suppliers.</p>

Support your research

Cell Culture

Expression

Labware / Accesories

Body Products

Technique Specific Products

Call +31 (0)26 326 44 50

Search results: DBF4

Didn't find what you were looking for?