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Bio-Connect Diagnostics

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TMPY-02150 | GADD45A Protein, Human, Recombinant (His & GST) | All TargetMol Chemicals products available at Bio-Connect | ISO certified | In-house tech support

GADD45A Protein, Human, Recombin... | TMPY-02150 | TargetMol Chemicals

GADD45A Protein, Human, Recombinant (His & GST)

We offer a wide range of chemicals that includes biochemicals, click chemistry products, inhibitors, small molecules, amino acid derivatives, antibiotics, (blocking) buffers, adjuvant, solvents and diluents as well as stains, labels and dyes.<br><br>You will find many categories within the assay product group, so you can select one to find the product you need quickly. Click on one of the categories for an overview of our products.

Bio-Connect offers a wide range of chemicals that includes biochemicals, click chemistry products, inhibitors, small molecules and many more.

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GADD45A is a member of the GADD45 Family, and has been found to associate with several cytoplasmic and nuclear factors and has been implicated in several cellular functions, including MAPK signaling, cell cycle regulation, DNA repair and genomic stability, apoptosis, and immune responses. The GADD45 Family of genes is rapidly induced by different stressors, including differentiation-inducing cytokines, and there is a large body of evidence that their cognate proteins are key players in cellular stress responses. GADD45A protein has been reported to interact with multiple important cellular proteins, including Cdc2 protein kinase, proliferating cell nuclear antigen (PCNA), p21Waf1/Cip1 protein, core histone protein and MTK/MEKK4, an up-stream activator of the JNK/SAPK pathway, indicating that GADD45A may play important roles in the control of cell cycle checkpoint, DNA repair process, and signaling transduction. GADD45A expression in response to genotoxic stress illustrates a more complex scenario, wherein transcriptional changes operate in concert with mRNA turnover and translational regulation. GADD45A was the first stress-inducible gene determined to be up-regulated by p53 and is also a target for the p53 homologues, p63 and p73. The decreased GADD45A expression is also considered a survival mechanism, as cancer cells without this control can evade the apoptotic pathway leading to increased tumourigenesis. As GADD45A is an essential component of many metabolic pathways that control proliferating cancer cells, it presents itself as an emerging drug target worthy of further investigation.

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