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ORB545764 | Human B7-H6 protein | Biorbyt available at Bio-Connect | Order online now!

Human B7-H6 protein | ORB545764 | Biorbyt

Human B7-H6 protein

The B7 family of genes is essential in the regulation of the adaptive immune system. one of which is the recently discovered B7H6. Humans and rats have a single B7H6 gene; however, many B7H6 genes were detected in a single large cluster in the Xenopus genome. Chimeric antigen receptor (CAR) T-cell therapies have demonstrated durable and potentially curative therapeutic efficacy against B-cell leukemia in clinical trials. In this study, B7H6, a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues.

natural killer cell cytotoxicity receptor 3 ligand 1

anti-B7H6 antibody is validated for WB & tested in Human. Arigo Biolaboratories is available at Bio-Connect

anti-B7H6 antibody antibody | ARG59729 | Arigo Biolaboratories

anti-B7H6 antibody

B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]

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