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SEC inhibitor KL-2 [900308-51-2]

SEC inhibitor KL-2 [900308-51-2]

T16868
TargetMol Chemicals
CAS Number900308-51-2
Product group Chemicals
Estimated Purity98.03%
Molecular Weight333.74
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    SEC inhibitor KL-2 [900308-51-2]
  • Delivery Days Customer
    9
  • CAS Number
    900308-51-2
  • Certification
    Research Use Only
  • Chemical Name
    SEC inhibitor KL-2
  • Estimated Purity
    98.03%
  • Molecular Formula
    C17H13ClFNO3
  • Molecular Weight
    333.74
  • Scientific Description
    SEC inhibitor KL-2 (KL-2) is a potent and selective inhibitor of the super elongation complex (SEC), showing a dose-dependent inhibitory effect on the AFF4-CCNT1 interaction with a Ki of 1.50 microM.
  • Shelf life instruction
    3 years
  • SMILES
    Cc1ccc(Cl)cc1NC(=O)C(\O)=C\C(=O)c1ccc(F)cc1
  • Storage Instruction
    -20°C
  • UNSPSC
    51202000

References

  • Liang K, Smith ER, Aoi Y, et al. Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy. Cell. 2018,175(3):766-779.e17. doi: 10.1016/j.cell.2018.09.027
    Read this paper

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