Secretory Iga

Athens Research

Secretory Iga

9

Infection, In Vitro Diagnostics, Autoimmune Diseases

Research Use Only

≥95% by SDS-PAGE. No reaction by IEP with antiserum to human Albumin, IgD, IgE, IgG, IgM and Lactoferrin

Secretory Immunoglobulin A (SIgA) is the predominant antibody found on mucosal surfaces, including the gastrointestinal, respiratory, and genitourinary tracts, as well as in secretions such as saliva, tears, and colostrum. Structurally, SIgA is a polypeptide complex composed of two IgA monomers, a joining (J) chain, and a secretory component, which protects it from enzymatic degradation and enables it to function in harsh environments like the gut. SIgA serves as the first line of immune defense by binding to pathogens and toxins, preventing their attachment and invasion of epithelial cells, a process known as immune exclusion. It also helps maintain mucosal barrier integrity and regulates the composition of the microbiota by interacting with commensal bacteria. Functionally, SIgA neutralizes viruses, bacteria, and other antigens without triggering strong inflammatory responses, thereby promoting immune tolerance and mucosal homeostasis. Clinically, altered SIgA levels are associated with increased susceptibility to infections, autoimmune diseases, and inflammatory conditions of the mucosa, making it a valuable marker for mucosal immune status and gut health.

more then 1 year

Prepared from human colostrum shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

≤ -20°C

12352202