sEH/AChE-IN-3 [2490589-11-0]

MedChem Express

sEH/AChE-IN-3 [2490589-11-0]

10

2490589-11-0

Research Use Only

C35H39ClF3N5O3

670.16

sEH/AChE-IN-3 (compound (-)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 0.4 nM (hsEH), 1.94 nM (hAChE), 615 (hBChE, human butyrylcholinesterase), 4.3 nM (msEH), and 2.61 nM (mAChE), respectively[1].

O=C(NC1=CC=C(OC(F)(F)F)C=C1)NC2CCN(C(CCCCNC3=C([C@]4([H])CC(C)=C[C@](C4)([H])C5)C5=NC6=CC(Cl)=CC=C36)=O)CC2

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