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ProductsBack/Selonsertib [1448428-04-3]

Selonsertib [1448428-04-3]

Research Use Only
SYN-1231
SYNkinase
CAS Number1448428-04-3
Product group Chemicals
Estimated Purity>95%
Molecular Weight445.5
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Overview

  • Supplier
    SYNkinase
  • Product Name
    Selonsertib (free base) [1448428-04-3]
  • Delivery Days Customer
    10
  • CAS Number
    1448428-04-3
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C24H24FN7O
  • Molecular Weight
    445.5
  • Scientific Description
    Chemical. CAS: 1448428-04-3. Formula: C24H24FN7O. MW: 445.5. Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation. - Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200