SEMA4B Protein, Mouse, Recombinant (His)

Biorbyt

SEMA4B Protein, Mouse, Recombinant (His)

10

Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 microg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.

Research Use Only

98.00%

Semaphorin-4B

Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling pathway, which subsequently inhibited cell growth through the direct nuclear target of FoxO1, p21. A role of SEMA4B in suppressing NSCLC growth, besides its role in inhibiting cell metastasis, and highlights SEMA4B as a promising therapeutic target for NSCLC.

Mouse

-20°C

12352202