SEMA4B Protein, Mouse, Recombinant (His)

TargetMol Chemicals

SEMA4B Protein, Mouse, Recombinant (His)

16

Research Use Only

75.7 kDa (predicted). Due to glycosylation, the protein migrates to 78-83 kDa based on Tris-Bis PAGE result.

Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling pathway, which subsequently inhibited cell growth through the direct nuclear target of FoxO1, p21. A role of SEMA4B in suppressing NSCLC growth, besides its role in inhibiting cell metastasis, and highlights SEMA4B as a promising therapeutic target for NSCLC.

-20°C

12352200