Semaxinib [204005-46-9]

TargetMol Chemicals

Semaxinib [204005-46-9]

4

204005-46-9

Chemical

Research Use Only

Semaxinib

99.84%

C15H14N2O

238.28

Semaxinib (SU5416) is a potent and selective VEGFR2 inhibitor (IC50: 1.23 microM), exhibiting a 20-fold greater selectivity for VEGFR2 over PDGFRbeta, with no activity against InsR, EGFR, and FGFR. Semaxinib reversibly inhibits ATP binding to the tyrosine kinase domain of VEGFR2, potentially inhibiting VEGF-stimulated endothelial cell migration and proliferation, thereby reducing tumor microvasculature.

3 years

C(=C1C=2C(NC1=O)=CC=CC2)C=3NC(C)=CC3C

-20°C

12352200