Senexin A (hydrochloride) [1780390-76-2]

MedChem Express

Senexin A (hydrochloride) [1780390-76-2]

14

1780390-76-2

Research Use Only

C17H15ClN4

310.78

Senexin A hydrochloride is an inhibitor of CDK8/19 (IC50: 280 nM, CDK8) and an inhibitor downstream of p21 transcription. It only inhibits p21-induced transcription but does not inhibit other biological effects of p21. Senexin A hydrochloride inhibits CMV-GFP induction as well as the p21 stimulatory activity of the consensus NF-kappaB-dependent promoters[1][2].

N#CC1=CC=C2C(C(NCCC3=CC=CC=C3)=NC=N2)=C1.Cl

12352200