Setidegrasib [2821793-99-9]

MedChem Express

Setidegrasib [2821793-99-9]

10

2821793-99-9

Research Use Only

99.65

C60H65FN12O7S

1117.30

Setidegrasib (KRAS G12D inhibitor 17, Example 8) is a PROTAC KRAS degrader (DC50: 37 nM). Setidegrasib induces the degradation of G12D-mutation KRAS protein. Setidegrasib has antitumor effect. (Blue: E3 ligase ligand (HY-168699); Black: linker (HY-168698); Pink: G12D ligand (HY-168700))[1].

CC(C(C(C(C1CC1)=CC(C(N2[C@@](CN3)([H])C[C@@]3([H])C2)=N4)=C5N=C4OC6CCOCC6)=C5OCC7=CC=C(C(N=N8)=CN8[C@@H](C(C)C)C(N(C[C@@H]9O)[C@@H](C9)C(N[C@H](C%10=CC=C(C(SC=N%11)=C%11C)C=C%10)CO)=O)=O)C=C7)=C(C=NN%12)C%12=C%13)=C%13F

-20°C

12131703