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Setipiprant [866460-33-5]

Setipiprant [866460-33-5]

T3520
TargetMol Chemicals
CAS Number866460-33-5
DownloadMSDS
Product group Chemicals
Estimated Purity99.16%
Molecular Weight402.42
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    Setipiprant [866460-33-5]
  • Delivery Days Customer
    9
  • CAS Number
    866460-33-5
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    Setipiprant
  • Estimated Purity
    99.16%
  • Molecular Formula
    C24H19FN2O3
  • Molecular Weight
    402.42
  • Scientific Description
    Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2, a G protein-coupled receptor for prostaglandin (PGD2), mediates key inflammatory responses related to allergy and asthma. PGD2, produced by mast cells, binds to CRTH2 on blood-borne cells, inducing chemotaxis of Th2 cells, basophils, and eosinophils, and stimulating cytokine release.
  • Shelf life instruction
    3 years
  • SMILES
    C(C(O)=O)N1C2=C(C=3C1=CC=C(F)C3)CN(C(=O)C=4C5=C(C=CC4)C=CC=C5)CC2
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

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