SF0166 [1621332-91-9]

TargetMol Chemicals

SF0166 [1621332-91-9]

114

Research Use Only

SF0166

C23H27F2N5O4

475.49

SF0166 is a potent, selective antagonist of alpha v beta 3, demonstrating IC 50 values of 0.6 nM for alpha v beta 3, 8 nM for alpha v beta 6, and 13 nM for alpha v beta 8. It effectively inhibits cellular adhesion to vitronectin in human, rat, rabbit, and dog cell lines, with IC 50 values ranging from 7.6 pM to 76 nM. Additionally, SF0166 significantly reduces neovascularization in the oxygen-induced retinopathy mouse model.

3 years

[C@@H](CC(O)=O)(N1C(=O)N(CCCC=2NC=3C(=CC2)CCCN3)CC1)C=4C=CC(OC(F)F)=NC4

-20°C

12352200