SGC0946

MedChem Express

SGC0946 [1561178-17-3]

10

1561178-17-3

Research Use Only

99.68

C28H40BrN7O4

618.57

SGC0946 is a selective DOT1L H3K79 methyltransferase ) inhibitor, with an IC 50 of 0.3 nM. SGC0946 results in G1 arrest, inhibits potential of cell self-renewal and metastatic, also induces cell differentiation. SGC0946 can be used in studies of leukemia and solid tumors and also serve as a probe to further investigate the cellular mechanism of DOT1L in both normal and diseased cells [1] [2] [3] .

NC1=NC=NC2=C1C(Br)=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CN(CCCNC(NC4=CC=C(C(C)(C)C)C=C4)=O)C(C)C)O3

-20°C,2°C to 8°C

12352200