
Western Blot Positive WB detected in: K562 whole cell lysate All lanes: SGMS1 antibody at 4microg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 49, 26 kDa Observed band size: 49 kDa
SGMS1 Antibody
CSB-PA801243LA01HU
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetSGMS1
Overview
- SupplierCusabio
- Product NameSGMS1 Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID259230
- Target nameSGMS1
- Target descriptionsphingomyelin synthase 1
- Target synonymshmob33; medulla oblongata-derived protein; MOB; MOB1; phosphatidylcholine:ceramide cholinephosphotransferase 1; protein Mob; SMS1; TMEM23; transmembrane protein 23
- HostRabbit
- IsotypeIgG
- Protein IDQ86VZ5
- Protein NamePhosphatidylcholine:ceramide cholinephosphotransferase 1
- Scientific DescriptionSphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC41116161