SGMS1 Antibody

Cusabio

SGMS1 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

SGMS1

sphingomyelin synthase 1

MOB, MOB1, SMS1, TMEM23, hmob33, phosphatidylcholine:ceramide cholinephosphotransferase 1, medulla oblongata-derived protein, protein Mob, transmembrane protein 23

Rabbit

IgG

Phosphatidylcholine:ceramide cholinephosphotransferase 1

Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.

Human

-20°C or -80°C

41116161