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ProductsBack/SGX-523 [1072116-01-8]
Chemical Structure
Chemical Structure
Chemical Structure

SGX-523 [1072116-01-8]

Research Use Only
SYN-1155
SYNkinase
CAS Number1072116-01-8
Product group Chemicals
Estimated Purity>95%
Molecular Weight359.4
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Overview

  • Supplier
    SYNkinase
  • Product Name
    SGX-523 [1072116-01-8]
  • Delivery Days Customer
    10
  • CAS Number
    1072116-01-8
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Hazard Information
    Warning
  • Molecular Formula
    C18H13N7S
  • Molecular Weight
    359.4
  • Scientific Description
    Chemical. CAS: 1072116-01-8. Formula: C18H13N7S. MW: 359.4. SGX523 is an ATP-competitive, triazolopyridazine-based inhibitor of MET at an IC(50) of 4nM. SGX523 has higher affinity for the unphosphorylated form of MET (Ki = 2.7nM) than the more active phospho-enzyme (Ki = 23nM). In a broad panel of 213 kinases, SGX523 was extremely selective, with no inhibition >36%, suggesting IC(50) values > 1microM, including the closely-associated RON kinase. - SGX523 is an ATP-competitive, triazolopyridazine-based inhibitor of MET at an IC(50) of 4nM. SGX523 has higher affinity for the unphosphorylated form of MET (Ki = 2.7nM) than the more active phospho-enzyme (Ki = 23nM). In a broad panel of 213 kinases, SGX523 was extremely selective, with no inhibition >36%, suggesting IC(50) values > 1microM, including the closely-associated RON kinase.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    51202000