SH-053-S-CH3-2F [872874-00-5]

MedChem Express

SH-053-S-CH3-2F [872874-00-5]

9

872874-00-5

Research Use Only

C23H18FN3O2

387.41

SH-053-S-CH3-2F is a selective positive allosteric modulator that produces mild to partial agonistic activity at alpha(1) GABA(A) receptors. SH-053-S-CH3-2F showed anxiety-relieving effects at a dose of 30 mg/kg. SH-053-S-CH3-2F completely avoids the memory impairment commonly caused by benzodiazepine site agonists. SH-053-S-CH3-2F shows strong selectivity at GABA(A) receptors, which could potentially be used to develop more selective anti-anxiety drugs[1].

O=C(C1=C2N(C=N1)C3=CC=C(C#C)C=C3C(C4=CC=CC=C4F)=N[C@H]2C)OCC

12352200