SH2D1A blocking peptide
GTX89320-PEP
Product group Proteins / Signaling Molecules
Overview
- SupplierGeneTex
- Product NameSH2D1A blocking peptide
- Delivery Days Customer9
- CertificationResearch Use Only
- Scientific DescriptionThis gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352202