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SH2D1A blocking peptide

Research Use Only
GTX89320-PEP
GeneTex
Product group Proteins / Signaling Molecules
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    SH2D1A blocking peptide
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Scientific Description
    This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352202