SH3GLB1 Antibody

Cusabio

SH3GLB1 Antibody

20

ImmunoFluorescence, ELISA

Research Use Only

Polyclonal

Unconjugated

SH3GLB1

SH3 domain containing GRB2 like, endophilin B1

Bif-1, CGI-61, PPP1R70, dJ612B15.2, endophilin-B1, Bax-interacting factor 1, SH3 domain-containing GRB2-like protein B1, SH3-containing protein SH3GLB1, SH3-domain GRB2 like endophilin B1, protein phosphatase 1, regulatory subunit 70, testicular tissue protein Li 172

Rabbit

IgG

Endophilin-B1

May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability.

Human

-20°C or -80°C

41116161