SHANK1 Antibody (OASE00177)

Aviva Systems Biology

SHANK1 Antibody (OASE00177)

23

Western Blot, ImmunoHistoChemistry, Other Application

Research Use Only

Monoclonal

S22-21

1 mg/ml

Unconjugated

Shank1

SH3 and multiple ankyrin repeat domains 1

Shank1a, Spank1, Sstrip, SH3 and multiple ankyrin repeat domains protein 1, GKAP/SAPAP-interacting protein, SAPAP-interacting protein synamon, SH3/ankyrin domain gene 1, SPANK-1, SSTR-interacting protein, somatostatin receptor-interacting protein, synamon

Mouse

IgG1

Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina (2). Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimers disease (3).

-20°C

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