SHANK1/SHANK3 Antibody (OASE00306)

Aviva Systems Biology

SHANK1/SHANK3 Antibody (OASE00306)

23

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry

Research Use Only

Monoclonal

S367-51

1 mg/ml

Unconjugated

Shank3

SH3 and multiple ankyrin repeat domains 3

Prosap2, Spank-2, SH3 and multiple ankyrin repeat domains protein 3, SH3/ankyrin domain gene 3, Shank postsynaptic density protein 3a, proline-rich synapse-associated protein 2

Mouse

IgG2a

SHANK proteins are scaffolding adaptors that have been shown to integrate neurotransmitter receptors into the cortical cytoskeleton at postsynaptic densities. SHANK1-3 of the SHANK/ProSAP family are molecular scaffolds in the postsynaptic density (PSD). SHANK recruits betaPIX and PAK to dendritic spines to regulate postsynaptic structure and interacts with ionotropic receptor and metabotropic glutamate receptor complexes. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development.

-20°C

12352203