Shikonin

MedChem Express

Shikonin [517-89-5]

10

517-89-5

Research Use Only

99.80

C16H16O5

288.30

Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC 50 of 6.5 microM [1] . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor [2] and can also inhibit TNF-alpha and NF-kappaB pathway [3] . Shikonin decreases exosome secretion through the inhibition of glycolysis [4] . Shikonin inhibits AIM2 inflammasome activation [7] .

O=C1C([C@H](O)C/C=C(C)/C)=CC(C2=C1C(O)=CC=C2O)=O

-20°C,2°C to 8°C

12352200