SHMT2 antibody
GTX125939
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetSHMT2
Overview
- SupplierGeneTex
- Product NameSHMT2 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:5000-1:20000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID6472
- Target nameSHMT2
- Target descriptionserine hydroxymethyltransferase 2
- Target synonymsGLYA, HEL-S-51e, NEDCASB, SHMT, mSHMT, serine hydroxymethyltransferase, mitochondrial, GLY A+, epididymis secretory sperm binding protein Li 51e, glycine auxotroph A, human complement for hamster, glycine hydroxymethyltransferase, mitochondrial serine hydroxymethyltransferase, serine aldolase, serine hydroxymethylase, serine hydroxymethyltransferase 2 (mitochondrial), serine methylase, threonine aldolase
- HostRabbit
- IsotypeIgG
- Protein IDP34897
- Protein NameSerine hydroxymethyltransferase, mitochondrial
- Scientific DescriptionThis gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Chu H, Zhao Q, Liu J, et al. Ionic Liquid-Based Extraction System for In-Depth Analysis of Membrane Protein Complexes. Anal Chem. 2022,94(2):758-767. doi: 10.1021/acs.analchem.1c03195Read this paper
- Liao Y, Wang F, Zhang Y, et al. Silencing SHMT2 inhibits the progression of tongue squamous cell carcinoma through cell cycle regulation. Cancer Cell Int. 2021,21(1):220. doi: 10.1186/s12935-021-01880-5Read this paper
- Zgheib R, Battaglia-Hsu SF, Hergalant S, et al. Folate can promote the methionine-dependent reprogramming of glioblastoma cells towards pluripotency. Cell Death Dis. 2019,10(8):596. doi: 10.1038/s41419-019-1836-2Read this paper
- Lin C, Zhang Y, Chen Y, et al. Long noncoding RNA LINC01234 promotes serine hydroxymethyltransferase 2 expression and proliferation by competitively binding miR-642a-5p in colon cancer. Cell Death Dis. 2019,10(2):137. doi: 10.1038/s41419-019-1352-4Read this paper
- Lo YW, Lin ST, Chang SJ, et al. Mitochondrial proteomics with siRNA knockdown to reveal ACAT1 and MDH2 in the development of doxorubicin-resistant uterine cancer. J Cell Mol Med. 2015,19(4):744-59. doi: 10.1111/jcmm.12388Read this paper
Datasheet
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