SHP099

MedChem Express

SHP099 [1801747-42-1]

10

1801747-42-1

Research Use Only

99.81

C16H19Cl2N5

352.26

SHP099 is an allosteric SHP2 inhibitor, with IC 50 s of 0.690, 1.241, 0.416, 1.968, 2.896 microM for SHP2, SHP2 D61Y , SHP2E69K, SHP2 A72V , SHP2 E76K . SHP099 inhibits cancer cell growth, such as MV4-11 and TF-1 cell (IC 50 : 0.32 and 1.73 microM). SHP099 inhibits RAS-ERK signaling and inhibits tumor growth [1] [2] .

NC1=NC(N2CCC(C)(N)CC2)=CN=C1C3=CC=CC(Cl)=C3Cl

-20°C,2°C to 8°C

12352200