SHP2-IN-23

MedChem Express

SHP2-IN-23 [2415989-91-0]

14

Research Use Only

C24H23ClN8S

491.01

SHP2-IN-23 (compound 30) is an orally active SHP2 inhibitor (IC50=38 nM) with excellent in vivo efficacy and pharmacokinetic profiles. SHP2-IN-23 inhibits ERK phosphorylation with IC50=5 nM[1].

N[C@H]1C2(CCN(C3=NC4=C(N=C(C=C4)SC5=CC=NC(N)=C5Cl)N=C3)CC2)CC6=NC=CC=C61

12131703