SHP2-IN-26

MedChem Express

SHP2-IN-26

14

Research Use Only

C20H22Cl2N6OS

465.40

SHP2-IN-26 (Compound 4b) is a highly selective SHP2 allosteric inhibitor with a IC50 value of 3.2 nM. SHP2-IN-26 inhibits the phosphorylation of ERK and AKT in NCI-H358 cells. SHP2-IN-26 has antitumor activity[1].

N[C@@H]1[C@H](C)OCC12CCN(C3=CN=C4C(NN=C4SC5=CC=CC(Cl)=C5Cl)=N3)CC2

12352200